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Notices2009-12-17: Please note that CIHR's Grants and Awards Guide has been updated. You can address any eligibility question to the CIHR funding guidelines contact found in this funding opportunity. The content of this funding opportunity has been updated Date updated: 2009-08-21 Section updated: Contact Information Date updated: 2009-08-10 Section updated: Important Dates (LOI Notice of Decision) |
Table of Contents
Description
The purpose of this funding opportunity is to further strengthen research on vision, hearing and communication disorders. It is expected that this targeted investment will lead to improved prevention, better treatment and more effective rehabilitation strategies. To achieve this objective, and to capture the interest and expertise in their respective research communities, the Institute of Neurosciences, Mental Health and Addiction (INMHA), in partnership with the Institute of Aging, are pleased to announce this joint support for multidisciplinary emerging research teams. Background Vision. The prevalence of Canadians with vision, hearing and communication disorders is high and increasing with the ageing of our population. Vision, hearing and communication disorders have a significant impact on daily life. The estimated blindness rate in Canada is 0.3%. Elderly people constitute the segment of the population most affected by loss of visual function. The prevalence of irreversible vision loss is increasing with 1 in 4 Canadians estimated to develop it by age 75. However, in more than 70% of cases, preventive or curative eye care can treat these problems. Three eye diseases account for the large majority of irreversible vision loss in Canada: age-related macular degeneration, glaucoma and retinal vascular diseases (such as diabetic retinopathy). Severe vision loss not only restricts communication via print and electronic media, but also leads to social isolation. Age-related macular degeneration (AMD) is the leading cause of legal blindness in Canada, with a prevalence of 1.2-1.4%. It affects 4% of people at age 60 and 25% of those 75 and over. In 2003, AMD was newly diagnosed in 80,000 Canadians. This situation will become worse due to longer life expectancy and a lack of large-scale preventive or curative treatments for this disease. AMD causes central vision loss. It has a major impact on daily life and recreational activities and the ability to communicate, and is especially debilitating at advanced ages when many other factors conspire to limit independence. Diabetic retinopathy (DR) is the leading cause of blindness in industrialized countries within the working-age group. The prevalence of diabetes is 3-5% (30,000-50,000 diabetics/million inhabitants). The prevalence of DR in diabetics is 20% (6,000-10,000 affected by DR/million inhabitants). The prevalence of blindness in those affected by DR is 5% (300-500 blind/million inhabitants, i.e., 5% to 10% of all cases of blindness). DR is associated with a higher mortality rate. In Canada, glaucoma is the second leading cause of irreversible blindness (7.5% of blindness in Canada). An estimated 328,000 Canadians currently have glaucoma (5,000 to 10,000 cases per million population, 600 to 1,000 of whom are blind). The prevalence of open-angle glaucoma increases significantly with age: from 1-2% in people aged 40 and over to 4-8% in people aged 80 and over. The prevalence of glaucoma is 16% in elderly people of African descent. As the population ages, the incidence, prevalence and impact of glaucoma will increase. Cataracts cause 3.5% of blindness in Canada. In people aged 50 and over, the prevalence of cataracts causing significant vision loss (< 6/12) is 30%. Prevalence increases dramatically between ages 50 and 90: 50% of people aged 70 to 80 and 100% of people over 90 have significant cataracts. More than one person in two will undergo cataract surgery in their lifetime. In developed countries such as Canada, cataracts are often considered a "conquered" disease because surgery can restore vision before visual loss becomes too pronounced. Nevertheless, cataracts result in significant vision loss in many elderly people. Cataract surgery waiting lists have been the focus of numerous healthcare policies. Wait times influence patients' degree of satisfaction. The key challenges to be met here are good planning of human and physical resources and sound management of surgery waiting lists. Retinopathy of prematurity (ROP) is the leading cause of blindness in children in industrialized countries. However, blindness can be prevented through screening and treatment. The key challenge is to identify children at risk of blindness (those with threshold retinopathy) and define criteria relating to birth weight or weeks of pregnancy in order to recognize the population at risk. Refractive disorders are another prevalent source of visual impairment, associated with substantial health-care costs. Myopia (near-sightedness) is very common, with an overall prevalence of ~25% in Canadian children and young adults; because the prevalence is so high, the costs of simple myopia (for eye examinations, corrective lenses and spectacles, and corneal surgery) approach $1 billion per year in Canada, and myopes are at risk of sight-threatening complications such as retinal detachment. Hearing. With regard to adult onset hearing loss: the prevalence of approximately 10% for those over 18 years of age, 20% for over 65, and 40% for over 75 years. Of the elderly in nursing homes it is estimated that 80% suffer from significant hearing loss. The incidence of hearing loss, as these numbers suggest, increases with age at a rate of approximately 5-6 dB per decade over the age of 55. Risk factors include: age, gender, noise exposure (leisure, recreational, occupational, military), systemic diseases (HIV, tuberculosis, cardiovascular, type 2 diabetes), substance abuse and otoxicity, many of which may show synergistic effects. Vulnerability to many of these factors also seems increasingly to follow from genetic predispositions. The burden of hearing loss includes social and psychological isolation, reduced quality of life, increased dependency and support needs. There are also significant economic costs in terms of health care and reduced income. The prevalence of sensorineural hearing loss exceeding 40 dB is estimated to be 1/1000 live births. In early childhood, causes of sensorineural hearing loss include single gene disorders, genetic syndromes, and non-genetic factors associated with pre-term birth, asphyxia, meningitis, kernicterus, intrauterine infections, and auditory neuropathy. By age 2 it is estimated that 70-90% of children have experienced at least one episode of middle ear disease and associated conductive hearing loss. Communication. The ability to communicate confers enormous advantages upon an individual. Language is integral to normal human development, cognition, and social relationships. It is estimated that one out of every six individuals suffers from some form of communication disorder during the course of life (National Institute for Deafness and Other Communication Disorders, National Institutes of Health). Communication disorders affect all factions of society, from infants and young children to the elderly; each disorder not only has an impact on specific aspects of communication, but has broader implications as well. As an example, hearing loss - the third most prevalent chronic disability among older adults (Canadian Association of Speech-Language Pathologists and Audiologists) - has a strong negative correlation with health and quality of life in aging. Not only are the individuals themselves affected but their family members, friends and colleagues as well. The social and economic costs of these communication disorders are particularly acute in modern economies where high levels of literacy are expected. We still have an incomplete understanding of the human communication process at all levels, from molecular and genetic determinants of basic sensory and motor developmental processes to the neural processes associated with speech and language and the causes and consequences of communication impairments. The consequences of this lack of fundamental knowledge is an inability to develop scientifically-based, targeted treatments - preventative or otherwise - to address the social, psychological and neurophysiological problems associated with developmental and acquired human communication disorders. Aging. The above disorders are exacerbated in the older population, in which defining and treating conditions is often complicated by the existence of multiple pathologies, cognitive and physiological impairments, polypharmacy, increased incidence of treatment-related side effects and other physiological changes. The CIHR Team Grant program funds expert teams (uni-disciplinary teams, multi-disciplinary teams, trans-disciplinary teams, community-partnered teams, academic-industry teams, etc.). Partners can include decision-makers, program administrators, care givers, policy makers and practitioners working in health-oriented community organizations, community-based foundations and organizations, local, provincial/territorial and national health charities and non-profit organizations, hospital and research institute foundations, municipal and regional health authorities, public health departments, district health councils, and provincial/territorial government agencies. Proposals that represent active and meaningful partnerships between community organizations and research teams based in institutions (including universities, colleges, hospitals, and affiliated research institutions) are encouraged. The unifying element underlying all successful CIHR Teams will be a commitment to excellence and the pursuit of a problem-based, collaborative approach to health research. Funds Available CIHR's contribution to the amount available for this initiative is subject to availability of funds voted annually to CIHR by parliamentary appropriations, and the conditions that may be attached to them.
Duration of Projects
Partner/Collaborator Participation CIHR is dedicated to identifying and developing collaborations with other funding organizations and stakeholders to enhance the availability of funding for this strategic initiative, and to create, where appropriate, opportunities for knowledge exchange and translation related to the scope of this particular initiative. Applicants are invited to visit the Partner/Collaborator Description section to find a list of partners/collaborators and their respective mandates and/or strategic interests. This list will continue to evolve as new partners/collaborators join in this initiative. The specific research foci and requirements for each partner/collaborator are outlined in the "Objectives" section. Top Objectives
The objectives of the CIHR Team Grant program are to:
For community-focused proposals, the guiding principle for participation is that community groups are active, influential and ongoing participants in the research, training, mentoring and knowledge translation activities, and that their roles have been formally agreed upon in the spirit of ensuring equity and mutual benefits from the partnership. It is expected that the partners will contribute to:
Information about knowledge translation can be found in the section "Defining and Framing Knowledge Translation" of the CIHR Knowledge Translation Strategy 2004-2009. Within the framework of the objectives of the CIHR Team Grant Program noted above, the specific objectives of this funding opportunity are:
Relevant Research Areas The CIHR Institute of Neurosciences, Mental Health and Addiction will provide funding for applications that are determined to be relevant to the following research areas:
The CIHR Institute of Aging will provide funding for applications that are determined to be relevant to the following research areas:
Top Eligibility
Please refer to the Eligibility Requirements for CIHR Grants and Awards regarding the eligibility requirements for individuals and institutions. The business office of the institution of an eligible Nominated Principal Applicant generally administers CIHR funds. Each eligible CIHR Team Grant application will include:
In addition, the following special conditions apply:
Randomized Controlled Trials (RCTs) will not be considered under this funding opportunity. Top Guidelines
This funding opportunity will follow the General Guidelines for Grant Programs. Applicants are encouraged to demonstrate the use of Gender and Sex-Based Analysis in applications. Allowable Costs Applicants should review the Use of Grant Funds section of the Tri-Agency (CIHR, NSERC and SSHRC) Financial Administration Guide for a complete listing and description of allowable costs and activities. Funding can be used to support:
With the exception of co-applicants who are trainees or research associates, co-applicants may not receive a salary, stipend, or honorarium from CIHR grants on which they are a co-applicant (as described in Participant Categories for CIHR Grants). The only exception is the release time stipends for the team leader and employees of community partners as described. The full application must provide a detailed justification of all costs. Conditions of Funding All conditions specified in CIHR General Grants and Awards Policies shall apply to applications funded through this Funding opportunity. Conditions cover areas such as Applicant and Institutional Responsibilities, Ethics, Official languages policy, Access to Information and Privacy Acts, and Acknowledgement of CIHR's Support. Successful applicants will be informed of any special financial requirements prior to the release of funds or when they receive CIHR's Authorization for Funding (AFF) document. In addition to CIHR standard guidelines and requirements, the following special conditions shall apply:
Access to Information Act and Privacy Act, and the Personal Information Protection and Electronic Documents Act (PIPEDA) All personal information collected by CIHR about applicants is used to review applications, to recruit reviewers, to administer and monitor grants and awards, to compile statistics, and to promote and support health research in Canada. Consistent with these purposes, applicants should also expect that information collected by CIHR may be shared as described in Use and Disclosure of Personal Information Provided to CIHR for Peer Review. CIHR as a federal entity is subject to the Access to Information Act and the Privacy Act, therefore the requirements of these two statutes will apply to all information located in CIHR's premises including, without limitation, cost-sharing agreements related to this Funding opportunity and all matters pertaining thereto. While respecting the application of the Privacy Act to federal entities, all signing parties involved in a collaborative agreement will also be bound by the Personal Information Protection and Electronic Documents Act (PIPEDA). All personal information (as identified by the PIPEDA) collected, used or disclosed in the course of any commercial activity under collaborative agreements related to the Funding opportunity will be collected, used and disclosed in compliance with the PIPEDA. CIHR Guidelines for Health Research Involving Aboriginal People The CIHR Guidelines for Health Research Involving Aboriginal People came into effect as policy for CIHR-funded research on July 1, 2008. Applicants whose proposed research will involve Aboriginal People are strongly encouraged to familiarise themselves with these guidelines and in particular with the section "Application of the Guidelines," which outlines the situations in which these guidelines apply. Policy on Access to Research Outputs CIHR believes that greater access to research publications and data will promote the ability of researchers and knowledge users in Canada and abroad to use and build on the knowledge needed to address significant health challenges. Open access will promote accessibility to CIHR-funded research and will serve to increase the international visibility of Canadian research. As of January 1, 2008, CIHR grant recipients are reminded to adhere with the responsibilities outlined in the Policy on Access to Research Outputs. Under this policy, grant recipients must make every effort to ensure that research papers and bio-molecular data generated from CIHR funding are freely accessible online. Communication Requirements In addition to following the policies relating to the Public Communication and Acknowledgment of CIHR's Support, team grant recipients will also be required to adhere to special branding requirements as a condition of receiving a CIHR Team Grant. The official Team name is "CIHR Team in (area of research)." In cases where there is another major funding partner a shared title should be considered. The format of a shared title is " CIHR/(partner name) Team in." The Team name must be used in all communication and promotion relating to the CIHR Team Grant. A team name must be proposed as part of the application for a CIHR Team Grant. Successful applicants and their host institutions will be required to agree in writing to proper use of the Team name as well as the CIHR (and applicable partners) logo(s) on appropriate communications materials such as brochures, letterhead, publications and media materials. Recognition guidelines, including instructions on logo use, will be provided to successful applicants as part of the approval package. Top Performance Measurement
CIHR is committed to demonstrating results to Canadians for the money invested in health research. Therefore, processes for monitoring progress and appropriate use of funds, as well as for performance measurement and program evaluation are in place. As a result, funding recipients must:
Top Review Process and Evaluation
Relevance Review Relevance review will be conducted at the Letter of Intent stage. Representatives from Institute of Neurosciences, Mental Health and Addiction and the Institute of Aging will have access to the anonymized Letter of Intent package and the one-page attachment describing how the proposed research addresses the objectives and relevant research areas (see "How to Apply") in order to determine relevance. At the full application stage, these representatives will have access to an updated version of the one-page attachment and the anonymized research proposal summary. The following criterion will be used in conducting relevance review.
Upon completion of peer review of the full applications, the representatives from Institute of Neurosciences, Mental Health and Addiction and the Institute of Aging will receive the ratings, rankings and peer review committee recommendations on funding level and term for the applications that are rated in the CIHR fundable range and are found to be relevant to the specific objectives of the research initiative and the research areas described under "Objectives" and "Relevant Research Areas." These applications will be funded from the top down in order of ranking as far as budgets will allow. Applications that receive a ranking below 3.5 will not be funded. Peer Review Eligible Letters of Intent (LOI's) and applications will be evaluated by a specifically-constituted, multidisciplinary peer review committee(s) designed specifically for the review of CIHR Team Grants. The committee may include individuals from partner communities. The expert committee may make suggestions to the applicants on how to strengthen their detailed proposal. It could, for example, suggest the grouping of complementary applications, and propose additional partnerships or funding sources. Once relevance has been determined and the review of LOI's is completed, selected applicants will be invited to submit a full application by the deadline date. All applications deemed relevant and rated 3.5 or above on the CIHR 0-4.9 scale will be invited to submit a full application The names of teams that will be invited to apply and the topic of their research will be published on the CIHR website. CIHR Team Grant applications will be evaluated as a single, integrated entity. While each research component included in the application must be meritorious, it is critical to demonstrate that the CIHR Team Grant brings added value, in terms of the approach to the health and disease, health care or health system issue, and the speed and efficiency with which new knowledge will be generated, or translated into improvements in health or the health care system, when compared with funding the proposed work as a series of separate operating grants. Evaluation Criteria General criteria for assessing applications are listed below. Because different applicant teams will emphasize different approaches to research and to knowledge translation, it is understood that reviewers and committees will weight questions such as these differently from one application to another. Address an important health and disease, health care or health system problem or issue:
Research proposed:
Applicants' productivity, experience and training:
Appropriateness of the Team:
Value added of funding through a collaborative program:
Propose a coherent, integrated and feasible research plan:
Provide superior training opportunities:
Propose an innovative problem-based approach to research:
Partner engagement:
Based on the total funds available for the competition, applications will be funded from the top-ranked down as far as budget will allow. Applications receiving a score less than 3.5 on the CIHR 0 to 4.9 rating scale will not be considered for funding. The CIHR rating scale is described in Policies And Responsibilities of Grants Committee Members. Top How to Apply
Note: This funding opportunity requires the use of CIHR Web Forms to apply for funding.
1) Letter of Intent (LOI)
Additional instructions that must be followed for this funding opportunity:
2. Application
Top Contact Information
Contact for questions about the research priority area Neurosciences, Mental Health and Addiction: Barbara Beckett (Updated: 2009-08-21) For questions specific to the CIHR Team Grant Program, including CIHR funding guidelines, how to apply, and the peer review process contact: Jo-Anne Whissell (Updated: 2009-06-30) For questions specific to the Randomized Controlled Trials program, including CIHR funding guidelines, how to apply, and the peer review process contact: Toni Gasparini
Top Partner/Collaborator Description
Note: Additional partners/collaborators, including partners/collaborators from industry and the private sector are expected to join this funding initiative over the coming year. Canadian Institutes of Health Research (CIHR) CIHR Institute of Institute of Neurosciences, Mental Health and Addiction (CIHR-INMHA) Partners CIHR Institute of Aging (CIHR-IA) Top |
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